Phospho-LAT (Tyr191) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16268-50, BZ16268-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O43561

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,IHC-P,ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Background: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry analysis of paraffin-embedded Human colon cancer using Phospho-LAT antibody. High-pressure and temperature Tris-EDTA pH 8. 0 was used for antigen retrieval. Sample withBlocking peptide on the right.

Bioworld Molecular Weight: Calculated MW: 28 kDa; Observed MW: 28 kDa

Specificity: IgG

Alternative Name: LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

Immunogen: The antiserum was produced against synthesized peptide derived from human LAT around the phosphorylation site of Tyr191. AA range:191-240

Conjugate: Unconjugated

Modification: Phosphorylated