Signal transducer and activator of transcription 6 fragment, (C54H81N13O15), a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3. STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.

Product information

Molecular Weight: 1152.30

Formula: C54H81N13O15

Chemical Name: 2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-hydroxypropanamido)-3-(4-hydroxyphenyl)propanamido]-3-(1H-indol-3-yl)propanamido}-3-hydroxypropanamido)-3-carboxypropanamido]-5-carbamimidamidopentanamido}-4-methylpentanamido)-3-methylpentanamido]-3-methylpentanoic acid

Smiles: CC(C)CC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CC1=CNC2C=CC=CC1=2)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(N)CO)C(=O)NC(C(C)CC)C(=O)NC(C(C)CC)C(O)=O

InChiKey: PCXDYSTYJAFWLF-UHFFFAOYSA-N

InChi: InChI=1S/C54H81N13O15/c1-7-28(5)43(52(80)67-44(53(81)82)29(6)8-2)66-50(78)37(20-27(3)4)62-46(74)36(14-11-19-58-54(56)57)60-49(77)40(23-42(71)72)64-51(79)41(26-69)65-48(76)39(22-31-24-59-35-13-10-9-12-33(31)35)63-47(75)38(61-45(73)34(55)25-68)21-30-15-17-32(70)18-16-30/h9-10,12-13,15-18,24,27-29,34,36-41,43-44,59,68-70H,7-8,11,14,19-23,25-26,55H2,1-6H3,(H,60,77)(H,61,73)(H,62,74)(H,63,75)(H,64,79)(H,65,76)(H,66,78)(H,67,80)(H,71,72)(H,81,82)(H4,56,57,58)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.