Will these interfere with jack point access?

No. These skirts are mounted above the rocker pinch points used for factory jacking. Verify your vehicle's OEM jack point locations before installation to confirm clearance with your lift equipment.

Do I need to prime and paint these before installing?

Not necessarily before install, but prep and paint before exposing them to weather. Sand the primer surface lightly to accept your chosen topcoat, then apply primer and color in the same sequence you'd use on any body panel repair.

What's the best way to bond these to the rockers?

These panels bolt to factory mounting locations using hardware available at any auto parts store. Bolting is the standard approach for FRP panels because it allows removal and replacement without damaging the substrate. Use corrosion-resistant fasteners and torque per your vehicle's service manual.