Does this cover require any adhesive, drilling, or permanent bed modifications?

No. The clamps mount directly to factory bed points. Once you're done using the cover, you can remove it completely without leaving holes or damage.

Can I open the cover while something's loaded in the bed?

The tri-fold design lets you fold it back against the cab, so partial bed access is possible without removing the entire cover. Full access requires either opening all three panels or taking the cover off completely.

Will I need to seal the seams or apply any coating before installation?

The cover ships ready to install. Seam conditioning or additional sealing is not required out of the box—fabric tonneau covers shed water naturally when properly tensioned across the bows.