Claudin-7 (phospho Tyr210) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4792-50, ES4792-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010],

Alternate Name: CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Claudin 7 around the phosphorylation site of Tyr210. AA range:162-211

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 32kD

Human Gene ID: 1366

Human SWISS Prot NO: O95471

Subcellular Location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Co-localizes with EPCAM at the basolateral cell membrane and tight junction.

Research Use Only