H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively.

Product information

CAS Number: 420841-84-5

Molecular Weight: 404.33

Formula: C21H12N2O7

Chemical Name: 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid

Smiles: OC(=O)C1=CC2=C(C=C1)C(=O)N(C1=CC(=CC=C1)OC1C=CC(=CC=1)N(=O)=O)C2=O

InChiKey: HFYPTENHTPNXGP-UHFFFAOYSA-N

InChi: InChI=1S/C21H12N2O7/c24-19-17-9-4-12(21(26)27)10-18(17)20(25)22(19)14-2-1-3-16(11-14)30-15-7-5-13(6-8-15)23(28)29/h1-11H,(H,26,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

H2L 5765834 displays no effect on LPA2 or LPA4 receptors. H2L 5765834 inhibits LPA-induced platelet shape change with an IC50 of 13.73±2.52 μM.

In Vivo:

H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model.

Products are for research use only. Not for human use.