K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.

Product information

CAS Number: 2376328-55-9

Molecular Weight: 561.07

Formula: C31H33ClN4O4

Chemical Name: 2-[5-chloro-2-cyclopropyl-3-(5-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-7-methyl-1H-indol-1-yl]-N-[1-(prop-2-enoyl)azetidin-3-yl]acetamide

Smiles: CC1=CC(Cl)=CC2=C1N(CC(=O)NC1CN(C1)C(=O)C=C)C(C1CC1)=C2C(=O)N1CC2=CC=CC(OC)=C2CC1

InChiKey: JESBUJUEMLEHDQ-UHFFFAOYSA-N

InChi: InChI=1S/C31H33ClN4O4/c1-4-27(38)35-15-22(16-35)33-26(37)17-36-29-18(2)12-21(32)13-24(29)28(30(36)19-8-9-19)31(39)34-11-10-23-20(14-34)6-5-7-25(23)40-3/h4-7,12-13,19,22H,1,8-11,14-17H2,2-3H3,(H,33,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (111.39 mM; ultrasonic and warming and heat to 60°C).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells.

Products are for research use only. Not for human use.