TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling. TPEN (TPEDA) may be a potential therapeutic strategy for APL (acute promyelocytic leukemia).

Product information

CAS Number: 16858-02-9

Molecular Weight: 424.54

Formula: C26H28N6

Synonym:

TPEDA

Chemical Name: N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine

Smiles: C(C1=CC=CC=N1)N(CC1=CC=CC=N1)CCN(CC1=CC=CC=N1)CC1=CC=CC=N1

InChiKey: CVRXLMUYFMERMJ-UHFFFAOYSA-N

InChi: InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 85 mg/mL (200.22 mM) Ethanol 85 mg/mL (200.22 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Bo Zhu, et al. Cell Physiol Biochem. 2017;42(5):1822-1836.

Products are for research use only. Not for human use.