Se-Aspirin is a novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID) . NSAIDs have demonstrated intestinal antineoplastic effects in various animal intestinal cancer models. Selenium (Se) compounds have attracted a vast interest as promising chemo-preventive agents. Several epidemiological studies have reported an inverse association between the nutritional Se status and cancer risk. Se functioned as chemo-preventive agent for cancer therapy in the past few years. Se-Aspirin was a hybrid of selenium and a nonsteroidal anti-inflammatory drug. t Se-Aspirin reduced the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells with the IC50 value of 3.4 μM. Se-Aspirin inhibited the cell cycle in G1 and G2/M phases and induced apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin has been reported to cause an increase in intracellular reactive oxygen species levels in CRC cells .

Product information

CAS Number: 1850293-95-6

Molecular Weight: 311.20

Formula: C12H12N2O3Se

Chemical Name: 2-{[2-(cyanoselanyl)ethyl]carbamoyl}phenyl acetate

Smiles: CC(=O)OC1=CC=CC=C1C(=O)NCC[Se]C#N

InChiKey: YJLOEJJBOLNYTM-UHFFFAOYSA-N

InChi: InChI=1S/C12H12N2O3Se/c1-9(15)17-11-5-3-2-4-10(11)12(16)14-6-7-18-8-13/h2-5H,6-7H2,1H3,(H,14,16)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.