N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin), a precursor of melatonin, is a potent and selective agonist of TrkB receptor.

Product information

CAS Number: 1210-83-9

Molecular Weight: 218.25

Formula: C12H14N2O2

Synonym:

NAS

N-Acetylserotonin

Normelatonin

O-Demethylmelatonin

Chemical Name: N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)acetamide

Smiles: CC(=O)NCCC1=CNC2=CC=C(O)C=C12

InChiKey: MVAWJSIDNICKHF-UHFFFAOYSA-N

InChi: InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 43 mg/mL (197.02 mM) Ethanol 43 mg/mL (197.02 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Sung-Wuk Jang, et al. Proc Natl Acad Sci U S A. 2010 Feb 23;

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