O4I2 is an Oct34 inducer which can induce expression of pluripotent-associated genes

Product information

CAS Number: 165682-93-9

Molecular Weight: 282.75

Formula: C12H11ClN2O2S

Synonym:

O-4I2

Chemical Name: ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate

Smiles: CCOC(=O)C1=CSC(NC2C=CC(Cl)=CC=2)=N1

InChiKey: ULUBAPWNHROTEU-UHFFFAOYSA-N

InChi: InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 28.3 mg/mL (100 mM) Ethanol: 14.1 mg/mL (50 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

O4I2 activates Oct3/4 expression in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts, and also induces other pluripotency-associated genes such as Lin28 and Nanog. [1]

References:

1. Cheng X, et al. J Med Chem. 2015 Aug 13;58(15):5742-5750.

Products are for research use only. Not for human use.