Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.

Product information

CAS Number: 1619971-30-0

Molecular Weight: 405.45

Formula: C21H23N7O2

Chemical Name: 1-{2-[(2,3-dihydro-1H-inden-2-yl)amino]-5H,6H,7H-pyrrolo[3,4-d]pyrimidin-6-yl}-2-[2-(2H-1,2,3-triazol-4-yl)ethoxy]ethan-1-one

Smiles: O=C(COCCC1C=NNN=1)N1CC2=NC(NC3CC4=CC=CC=C4C3)=NC=C2C1

InChiKey: ILOFWCAZDNILKY-UHFFFAOYSA-N

InChi: InChI=1S/C21H23N7O2/c29-20(13-30-6-5-17-10-23-27-26-17)28-11-16-9-22-21(25-19(16)12-28)24-18-7-14-3-1-2-4-15(14)8-18/h1-4,9-10,18H,5-8,11-13H2,(H,22,24,25)(H,23,26,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours. Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h.

Products are for research use only. Not for human use.